SETTLE

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Kari

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Hi,

We're making one last stab at getting Patty, Tigger's mom, in foal. She's being retired next year, regardless of what happens.

Patty has Endometriosis, so has difficulty settling........ she can't without help. Right now we're trying oxytocin shots after she's bred. We don't know yet if these shots have worked.

Have you heard of or tried the product called SETTLE? It reportedly has a success rate of 75%.

SETTLE

Vaccines are shipped by air & packaged on ice packs in an insulated styrofoam box.

During check out Please select "Vaccines/ Refrigerated items" for shipping method.

SETTLE for horses is a MYCOBACTERIUM CELL WALL FRACTION IMMUNOSTIMULANT. SETTLE is recommended as an aid in the treatment of equine endometritis caused by Streptococcus zooepidemicus. 1.5ml ds

Item# Item Name Allivet Price Qty Add

28733 SETTLE - 1 ds $54.99

Check the items you wish to purchase, then click

Features:

1.5ml ds

Technical Specs:

Dosage & Administration: Administer 1.5 ml by intrauterine instillation with a sterile catheter or by intravenous injection into the jugular vein during the early estrus period. Treatment may be repeated at subsequent natural or induced estrus periods.

Intravenous:Administer 1.5ml of SETTLE by intravenous injection into the jugular vein during the early estrus. Use strict aseptic technique.

Intrauterine: Administer 1.5ml by intrauterine instillation using strict aseptic technique. Dilute 1.5ml of SETTLE in sterile lactated ringers, normal saline, water for injection or semen extender to provide an approximate final volume of 25-50ml. Aseptically administer the diluted solution into the uterus using a sterile catheter.

CAUTION: Store at 2°-7°C. (35°-45°F). Do not freeze. Mix thoroughly before injecting. Use entire contents when first opened. Contains gentamicin as preservative. Do not administer within 21 days of slaughter. If anaphylaxis occurs, administer epinephrine or equivalent. KEEP OUT OF THE REACH OF CHILDREN.

Contra-indications: Cortisone reduces the production of interleukin-1 (IL-1). Mares being treated with corticosteroids or ACTH may not respond to SETTLE therapy.

Product Description:SETTLE is an emulsion of purified mycobacterium cell walls that have been extracted by a process that reduces their toxic and allergic effects. SETTLE enhances the innate humoral immune responses by activating macrophages and stimulating the cloning of polymorphonuclear leukocytes (PMN). These activated phagocytic cells stimulate a cytokine cascade that results in the destruction of bacteria, such as Streptococcus zooepidemicus.

Side Effects: Mild fever, drowsiness, and decreased appetite may occur for 1 to 2 days following intravenousinjection. These are normal responses to the release of IL-1. An elevated body temperature enhances the immune function by stimulating leukocyte activity and thus is not an adverse side effect.

How supplied: SETTLE is available in cartons containing 6 x 1.5ml single dose vials.

Manufactured by: Bioniche Animal Health USA, Inc., Athens, GA 30601

Thanks for any help!!!

Kari
 
If that is your only problem, and there is no damage to your mare's uterine walls (as indicated by a biopsy), then it may help. Remember that the trials, even if they were double blind and well managed by a reputable scientific agency, were almost guarenteed to be skewed to promote the drug. In this case chances are EVERY mare in the trial that had endometritis had it due to this single bacterial organism. Therefore, IF that is your mare's only problem, chances are it would help.

Your other option might be embryo transfer, if the mare justifies the expense. There are clinics out there that are working with miniature donar mares.
 
Thank you for the insight, Nathan.

Does anyone else have experience with this drug?

Kari
 

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