Not sure what you mean by "two sides of the gene", Jane? However, what you spoke of in Dobermans is very possibly exactly the same KIND of thing that is happening genetically to produce dwarves in Miniature horses! That would be, that the gene or gene 'group' that is responsible is a 'simple' recessive-which, to put it more simply than it may well be???-means that when an animal carries only ONE copy, there is no manifestation of characteristics, but when a fetus gets TWO copies(one from each parent), then the characteristic will be manifested in the that offspring.No, we do NOT 'KNOW' if this Mendelian model actually IS what is happening, but it is likely, based on what IS already known! Of COURSE, this is why research IS needed!
When you cite being able to determine that an animal is 'Clear, Affected, or Carrier'--well, YEAH! This is almost CERTAIN to be what IS going on with miniature horses and dwarfism-and that the cause of dwarfism will indeed prove to be exactly this! When there is a genetic test to determine which one any given miniature horse IS, then anyone conscientiously breeding miniatures could almost certainly make sure that no further dwarves were born...how? By exactly what you said--breeding only KNOWN 'Clear' to KNOWN 'Clear', or KNOWN 'Clear' to KNOWN 'Carrier'! You would not produce any dwarves, though you might well produce more 'Carriers'. I believe this is exactly what is being done in Arabians, with CID, and in American Quarter Horses, with HYPP-with research, both the genetic cause AND how to identify which horses carried the gene,was identified. Then, a program was instituted to try to insure, basically, that 'Carriers' are NEVER bred to 'Carriers'! I don't know how controlled their programs are-that is, whether it is RULES, or just 'suggestions'-from what I've read, AQHA is moving to not allowing ANYTHING that tests positive for even one copy of the HYPP gene to be bred, period(or at least, no such offspring would be registered); don't know about the Arabian registry-but do know, that if I were shopping for either breed, I would want to know the horse's test results!
THIS is why,NOW, my position on any further breeding of ANY stallion OR mare that has produced one of the known, 'conventional' types of dwarf, would be the same as others, notably like Outlawridge, and Sue C., have expressed. I would not ever breed either animal again, and would do my best to ensure that NO ONE ever bred either again. This eliminates the 'crapshoot' that now is the case-not only of producing more dwarves, but of producing more UNKNOWN carriers, which take the problem on, and on-and no rationalizations will change that. I do not believe that 'every miniature horse carries the gene for dwarfism'-plain logic and my basic knowledge of Mendelian genetics make me believe that--nor do I think that the 'gene pool' would be in serious trouble, even now, before research has provided the information we so badly need, if known producers of dwarves were to all be dropped from breeding. There would certainly be those who would be 'hit' in the pocketbook, though--and many won't tolerate that....I didn't want to, either, around 9 years ago when I 'lost' the $5000 I'd paid for a breeding stallion, and gave away, to a youth-at-risk charity,both he and two pretty nice mares I'd raised(one was a perfectly nice, normal-looking daughter of the stallion, and I didn't feel right about selling her-the other was the dam of the dwarf-also quite decent and normal-looking)--but, I did what I felt I must do. (I now realize it would have been better had I gelded the stallion, but at least, the charity wasn't into breeding.)I did tell the receipients about the dwarf.
I admire Liz M. for her committed study of the aspects of dwarfism! Although I do agree that often, there are certain characteristics that seem to "point to" the possibility that a given horse might well produce a dwarf, I do think that sometimes, seriously affected dwarves do come from very normal-appearing, and in some cases, quality-appearing, parents. Recently, I have seen various photos, in various places, of Miniatures that I call"hot dogs with legs". These kinds of horses are some I would never breed. Just my honest opinion, and assessment. I DO hope that research will move forward on this subject; however, since the donation check I mailed to the university program that was supposed to be moving on this has never been cashed, after months, I have to wonder....
Margo