Were you able to identify equine dwarf genes in common

[Bluerocket]

Thank you for your time.

With the data you have accumulated from your studies -- have any "dwarf" genes been identified that are found in common between species (like equine and human)?

My understanding is that there are many genes contributing to dwarfism in equines -- rather than one or two specific genes.

Judith Jay (former owner of Nutmeg and Clove - dwarf minis in your study).

 

[Arion Mgmt]

JJay,

There are no known dwarf genes identified in the horse genome, meaning all horse breeds, compared to the dwarf genes known in the human. There are numerous known dwarfisms that are characterized and sequenced in the human, mouse, and cattle. These are what I am using to compare to as candidate genes.

I am the only one I know that has the samples needed, the pedigrees, and other inheritance pattern info needed to do this right. What I am doing is using the candidate gene approach to try to find the dwarf genes in the horse, which really are normal genes that have been mutated. This approach uses known genes in other mammals that have been found sequenced and characterized as producing a specific dwarf disease. I then try to see if certain known mammal dwarf diseases characterized, match as close as possible to the PHYSICAL characteristics of these dwarfs to then take that known gene and then compare it to the horses unknown gene. Each try is a true shot in the dark, that is why physical characterization, ie, digital xrays and necropsies are necessary to keep the shots in the dark to a minimum.

Right now I feel there are mutiple genes involved to cause the different types seen. meeaning one defective gene one type of dwarfism.

John